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STING activator Compound 53

CAS No. 2259624-71-8

STING activator Compound 53( 1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide )

Catalog No. M28935 CAS No. 2259624-71-8

STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    STING activator Compound 53
  • Note
    Research use only, not for human use.
  • Brief Description
    STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
  • Description
    STING activator Compound 53 based on an oxindole core structure demonstrated robust on-target functional activation of STING (human EC50 185 nM) in immortalised and primary cells and a cytokine induction fingerprint consistent with STING activation.
  • In Vitro
    STING agonist-12 (Compound 53) (10 μM) shows excellent pan-polymorph activity across the panel of STING proteins (92%, 107% and 92% against R232, H232 and HAQ, respectively) in HEK293T cells.STING agonist-12 is not active at mouse STING.
  • In Vivo
    STING agonist-12 (Compound 53) (5 mpk for i.v.; 10 mpk for p.o.) is well-absorbed with a short terminal half-life. Animal Model:Balb/c mice (n=3) Dosage:5 or 10 mpk Administration:Lateral tail vein or oral gavage (Pharmacokinetic Analysis)Result:Pharmacokinetic profile of STING agonist-12 (Compound 53) in mouse.
  • Synonyms
    1-(2-chloro-6-fluorobenzyl)-3,3-dimethyl-2-oxo-N-(2,4,6-trifluorobenzyl)indoline-6-carboxamide
  • Pathway
    Immunology/Inflammation
  • Target
    STING
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2259624-71-8
  • Formula Weight
    490.88
  • Molecular Formula
    C25H19ClF4N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (509.29 mM)
  • SMILES
    CC(C)(c(ccc(C(NCc(c(F)cc(F)c1)c1F)=O)c1)c1N1Cc(c(F)ccc2)c2Cl)C1=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Gao Y, et al. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. Cell Death Dis. 2016 Aug 11;7(8):e2330.
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